Isibonelo, ukuqeqeshwa kwesisindo futhi uhlobo lokucindezeleka. Ochwepheshe bazoqinisekisa ukuthi babangela ukuhlukana okuncane emicimbini ye-muscle ... nokuphulukiswa kwalezi zilonda kuba yisisusa ekukhuleni nasekuthuthukiseni imisipha. Isiqinisekiso sokuqala esicindezelayo emithini encane singaba nemiphumela emihle eziphilayo eziphilayo ezitholwa ummese waseJalimane uHugo Schulz ngasekupheleni kwekhulu le-19. Wathola ukuthi imvubelo yaqala ngokuqina uma ingeza izinto ezinobuthi. Lesi senzakalo kamuva sabizwa ngokuthi "hormesis", kusukela esiGrekini sasendulo "injabulo, ukuvuselela". Kubonakala lapho iziphilayo eziphilayo zibhekene namancane amachiza, ama-poisoni, amazinga okushisa aphezulu kanye neminye imiphumela eyingozi. Uma lezi zilinganiso zincane kakhulu kangangokuthi azikwazi ukulimaza kakhulu, sibona isithombe esiphikisanayo: ukulungisa umonakalo omncane, umzimba uvuselela izinsiza zangaphakathi futhi awubuyiseli kuphela umonakalo, kodwa uthuthukise isimo samathambo uma kuqhathaniswa nesimo sangempela. Ukuze uthole imininingwane, bheka isihloko esithi "Umphumela wokulala nokucindezeleka kwesikhumba sempilo".
Umphumela we-Microdose
Isazi sezinto eziphilayo esidumile emhlabeni wonke u-Suresh Rattan waseNyuvesi yase-Aarhus (eDenmark) sicele ukusetshenziswa kwe-hormesis yokulwa nezinguquko ezihlobene nobudala. Wabonisa ukuthi ukuvezwa okuvamile ezincane zokulinganisa ukucindezeleka kuvuselela ukusabela kwamaseli futhi kunciphisa inqubo yokuguga. Ukucindezeleka okuzuzisa okunjalo kungenza imiphumela yomzimba (izinga lokushisa eliphezulu, imisebe ye-UV, imithwalo yemidlalo), imikhuba yokudla (ukudla okuphansi kwekhalori, imikhiqizo ethile - i-turmeric, i-ginger nabanye), izimo ezingokwengqondo (isibonelo, injabulo ngaphambi kokusebenza emphakathini). Ngo-2002, uRattan nabalingani bakhe bafunda umphumela wezinkinga ezincane zokucindezeleka ngokuhlanganiswa kwamaprotheni ekuguga fibroblasts (amaseli aphethwe ukukhiqizwa kwe-collagen ne-elastin). Ososayensi babe nesithakazelo kwenye yezinto okuthiwa i-heat shock proteins (HSP70), okubandakanyeka ekuphenduleni komzimba ekucindezelekeni. Ngemuva kokwethuka kokushisa okulinganiselwe, izinga laleli protheyinti emangqamuzaneni landa, futhi nalo - ukuphikiswa kwe-ultraviolet nezinye izinto ezinobuthi. Amangqamuzana asegugile asebenza kakhulu futhi aphephile.
Umgomo wokulwa nokuguga
Ephefumulelwe ukutholakala, ososayensi bama laboratories bahlangana neqembu labososayensi abaholwa nguRattan futhi badala i-serum eguga ukuguga neyinkimbinkimbi yezithako ezisebenzayo, okuvusa ama-hormomine, ama-hormomine. Kulesi simo, zenza iqhaza ekukhiqizeni la maprotheni futhi ngaleyo ndlela zivimbela inqubo yokuguga. Le nkimbinkimbi ihlanganisa ukukhishwa kwe-ginseng Sanchi ne-gipotaurin, etholakala ku-taurine - enye yama-amino acid ekhona emzimbeni womuntu.
Imiphumela
Esikhathini sezifundo, kwatholakala ukuthi, amahora ayisithupha emva kokusetshenziswa kwe-serum, ukukhiqizwa kwe-HSP70 amaprotheni amangqamuzana kwanda ngamaphesenti angu-24. Ukuhlolwa komtholampilo kubonise ukuthi ukumelana kwesikhumba emithonjeni yangaphandle emva kwenyanga ukusebenzisa i-serum kwanda ngo-3%. Ngempela, i-microstress iqala ukwakhiwa kwezinto ezintathu zokuphendula izidakamizwa emzimbeni futhi kusebenze kufaka phakathi ukushisa kwamaprotheni. Ama-hormetin awasizi nje kuphela amangqamuzana ukumelana nokuguga, kodwa futhi akhulise ubude bokuphila okusebenzayo kweseli. I-dermatologists ne-cosmetologists ehamba phambili eYurophu ehamba phambili iyavuma ukuthi ukusetshenziswa kwemikhiqizo yokunakekela isikhumba ngokusekelwe ekujuleni okujulile kwezinto eziphilayo zomzimba kanye ne-biochemistry ekuqondeni izakhiwo zokubuyiselwa kwezicubu eziphilayo zingaletha impumelelo enkulu. Into esemqoka ukuqinisekisa ukuthi basebenzise kahle. Manje siyazi ukuthi kuthini ukulala nokucindezeleka empilweni yesikhumba.