Indima yesimiso sokuvikela omzimba ekuzalweni komuntu iphezulu kakhulu. Ososayensi baye bafakazela ukuthi cishe abantu abayisishiyagalolunye babantu abangenalwazi abangenalutho banezinkinga ngesistimu yomzimba. Esinye sezici ezihlobene nesistimu yesimiso sokuzivikela, okungabangela ukungasebenzi, kungukuqala kwamagciwane antispermal.
Lezi zidumbu zithatha inqubo yokusebenzisana kwama-gametes (gametes), engavumeli i-spermatozoa ukungena kwigobolondo leqanda. Indlela abenza ngayo lokhu engakacaciswanga ngokugcwele, kodwa kakade kucacile ukuthi lezi zinqamuzana zivimbela impendulo ye-acrosomal yamaseli e-spermatozoon, okwenza njengenye yezici ezidingekayo zokufaka umquba ophumelelayo. Uma omunye wabalingani, amadoda noma abesifazane, enemizimba ye-antispermic, khona-ke izinga lemibungu libi nakakhulu kunelabantu abangenayo imizimba enjalo, okunciphisa ukusebenza kokwelashwa okungenasifo sokubeletha nge-in vitro fertilization. Uma i-ACAT ingaphathwa ngempumelelo ngamasu okuqapha, indlela ekhethwayo kakhulu yamabhulozi anjalo ukufakwa kwe-spermatozoa eqanda (i-ICSI).
Izindlela zokunquma antibodies antisperm kubesifazane
Kubamele abesilisa ababuthakathaka, ama-anti-antibodies antisperm anqunywe emgqonyeni wesibeletho nasemanzini e-plasma. Kuphoqelekile ukuhlola ukutholakala kwama-antibodies anjalo kulezo zibhangqwana ezilungiselela IVF.
Esivame kakhulu ekunqumeni kwama-antibodies antisperm, izindlela ezisuselwa ekunqumeni kwamagciwane okubhekiswe kuma-antigens we-membrane asetshenziswa. Lezi zihlanganisa izindlela ezifana nalezi:
- Isivivinyo sokusebenzisana kwe-spermatozoa nge-membrane yamangcwaba yomlomo wesibeletho, noma i-postcoital. Kumele kukhunjulwe ukuthi esinye sezimbangela ezivame kakhulu zokuhlolwa kwe-postcoital embi ukuthi kukhona i-ACAT emvuleni, okungukuthi, inkinga ihlobene nendoda, hhayi emtholampilo. Kodwa-ke, ngokuvamile kuvame ukugcina inhlanganisela yezimbangela zesifazane nabesilisa. Ukuhlolwa kwe-Postcoital akulona okunokwethenjelwa kakhulu lapho kuhlola ukungabi nabantwana futhi kuye iphesenti yedatha yamanga iphezulu kakhulu. Yingakho engasetshenziswanga yedwa, kuphela kanye nolwazi oluvela ocwaningweni ku-ACAT;
- UM MAR-ukuhlolwa. Lena inqubo evumela ukuthi wena unqume inani le-spermatozoa ehlotshaniswa nama-antibodies eklasini IgA ne-IgG, futhi kusiza ukwazi i-titer ye-antisperm antibodies kuleso siphuzo sezinto eziphilayo njenge-mucus yomlomo wesibeletho, i-spermoplasm, i-plasma yegazi. Lokhu kuhlolwa kubonakala emhlabeni jikelele njengendlela yokuhlola ye-ACAT, inokuzwela okulinganiselayo kanye nokucaca okuphezulu;
- Ukuhlolwa kwe-latex agglutination yi-test ye-ACAT esanda kuthuthukiswa futhi ayihlolwe ngokuphelele. Lokhu kuhlolwa kuyindlela ecacile yokuqaphela i-ACAT emithonjeni yezinto eziphilayo, njenge-plasma yegazi, i-semen, i-mucus yomlomo wesibeletho. Unokuzwela okukhulu. Iqoqo lama-antibodies angatholakala ukuthi lisebenzisa le ndlela akuhambisani ngaso sonke isikhathi nesethi yamagciwane okutholwa yizivivinyo ezimbili zangaphambilini, ngakho bavame ukuhlanganiswa ukuthola imiphumela ethembeke kakhulu;
- I-ELISA (i-enzyme immunoassay) - isetshenziswa kakhulu ukucinga i-ACAT eplasma yegazi. Kuthathwa njengenye yezindlela ezengeziwe zokuthola i-ACAT. Izihloko ezinkulu ze-ACAT, ezithathwe yilo ndlela e-plasma yegazi kulabo besifazane, zingase zingabanjiswa nokuwohloka kokuqala kokukhulelwa.
Izindlela zokwelapha
Ukwelashwa kwemibhangqwana okuye kwatholakala ukuthi kunezinga eliphezulu le-ACAT kungenziwa ngezindlela ezehlukene, kuye ngokuthi imiphumela yokuhlolwa. Okokuqala, ezimweni eziningi, indlela yokuvimbela isetshenziswa, okungukuthi, ikhondomu, ngokusetshenziswa njalo isikhathi sezinyanga ezingu-2-5 noma kwimodi ephakathi, lapho ikhondomu ingasetshenziswanga kuphela ngalezo zinsuku ezikhangayo ukubonakala kokukhulelwa.
Ukunciphisa inani lezinyosi ezingena emzimbeni womuntu wesifazane kubangela ukunciphisa ukuhlanganiswa kwama-antibodies futhi kwandisa amathuba okukhulelwa.
Ngesikhathi esifanayo, ukwelashwa kungabekwa, okunciphisa i-viscosity ye-mucus yomlomo wesibeletho kanye nokuvimbela ukuhlanganiswa kwe-ACAT emishadweni. Uma izindlela zokuzimela zingasiza, khona-ke ziya ku-ISKI.