UMonica akazange afune ukwakha umsebenzi owenzayo. Wayefuna ukuba ngummeli omuhle, futhi ukuze angene eyunivesithi, wasebenza njengesibonelo ngesikhathi eneminyaka engu-16. Kodwa ngokushesha wazithandana nokuphila komphakathi futhi wanquma ukuqhubeka ethanda ukukhazimula, edela iphupho lakhe lokuba ngummeli.
UMonica wayekhuluma kahle ngezilimi eziningana, njengesiNgisi, isiFulentshi, isiNtaliyane nesiSpanish esincane.
Indima ebalulekile eyathola ngo-1992, ngesikhathi enikezwa indima yokuba ngumlobokazi kaDracula kule filimu "Dracula". Ngemuva kwalolu daba, wathola izipesheli ezintsha ezivela ezinkampanini ezidumile zefilimu e-Europe naseMelika. Impumelelo kaMonica iza ngemuva kokubamba iqhaza kule movie "Apartment" ngo-1996 futhi uthola umklomelo "Cesar". Kwakunesikhathi sokuqopha le filimu ukuthi uMonica wazi kahle umyeni wakhe wesikhathi esizayo uVincent Cassel. Wabuye wabamba inkanyezi ku-movie ye-Action Action yaseFrance.
Kusukela ngo-1997 ukuya ku-1998, uMonica wabhekana nezinkomba ezingu-7: "Ukucindezeleka", "Isimo Esimbi", "Ufuna Ngami", "Isifiso", "Ngeke Kube Iholide", "Ngabe Labo Abathandayo", "Ukuncintisana". Kodwa ngalokhu uBellucci akazange ayeke, wathola iziphakamiso ezintsha, kodwa akazange agijimele ukuvela kuzo zonke ifilimu ayezinikezwa. UMonica wayefuna kakhulu imisebenzi ehlongozwayo. Wakhetha kuphela lezozindima lapho angamkhombisa khona ithalenta elisebenzayo.
Eyaziwa emhlabeni wonke njengesibonelo nomlingisi, uMonica uvela emaphethini omagazini abaluhlaza. UBellucci ekugcineni wabonisa ithalenta lakhe ebhayisikobho "Malena", ekutholeni izinhliziyo zabo bonke ababukeli nabagxeki. Ukumisa kumafilimu omunye uhlobo uMonica akakaze afise, ngemuva kokuba anqume ukwenza ifilimu kwifilimu enzima ethi "Passions of Christ".
UBellucci akayeki kuze kube manje futhi udutshulwa kumafilimu ahlukahlukene, eba ngumdlali wesigaba sokuqala eHollywood.
UMonica naye waba ubuso be-"Royal Velvet" inkampani u-Oriflame nobuso be-cosmetic line i-Dolce & Gabbana.